Specific Increase in MDR1 Mediated Drug-Efflux in Human Brain Endothelial Cells following Co-Exposure to HIV-1 and Saquinavir

Persistence of HIV-1 reservoirs within the Central Nervous System (CNS) remains a significant challenge to the efficacy of potent anti-HIV-1 drugs. The primary human Brain Microvascular Endothelial Cells (HBMVEC) constitutes the Blood Brain Barrier (BBB) which interferes with anti-HIV drug delivery...

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Detalles Bibliográficos
Autores principales: Roy, Upal, Bulot, Christine, Honer zu Bentrup, Kerstin, Mondal, Debasis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789726/
https://www.ncbi.nlm.nih.gov/pubmed/24098380
http://dx.doi.org/10.1371/journal.pone.0075374

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789726/
https://www.ncbi.nlm.nih.gov/pubmed/24098380
http://dx.doi.org/10.1371/journal.pone.0075374

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