Inhibition of Pyrimidine Biosynthesis Pathway Suppresses Viral Growth through Innate Immunity

Searching for stimulators of the innate antiviral response is an appealing approach to develop novel therapeutics against viral infections. Here, we established a cell-based reporter assay to identify compounds stimulating expression of interferon-inducible antiviral genes. DD264 was selected out of...

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Detalles Bibliográficos
Autores principales: Lucas-Hourani, Marianne, Dauzonne, Daniel, Jorda, Pierre, Cousin, Gaëlle, Lupan, Alexandru, Helynck, Olivier, Caignard, Grégory, Janvier, Geneviève, André-Leroux, Gwénaëlle, Khiar, Samira, Escriou, Nicolas, Desprès, Philippe, Jacob, Yves, Munier-Lehmann, Hélène, Tangy, Frédéric, Vidalain, Pierre-Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789760/
https://www.ncbi.nlm.nih.gov/pubmed/24098125
http://dx.doi.org/10.1371/journal.ppat.1003678

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789760/
https://www.ncbi.nlm.nih.gov/pubmed/24098125
http://dx.doi.org/10.1371/journal.ppat.1003678

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