Practical Considerations Regarding the Use of Genotype and Pedigree Data to Model Relatedness in the Context of Genome-Wide Association Studies

Genome-wide association studies of complex traits often are complicated by relatedness among individuals. Ignoring or inappropriately accounting for relatedness often results in inflated type I error rates. Either genotype or pedigree data can be used to estimate relatedness for use in mixed-models...

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Detalles Bibliográficos
Autores principales: Cheng, Riyan, Parker, Clarissa C., Abney, Mark, Palmer, Abraham A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2013
Materias:
Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789811/
https://www.ncbi.nlm.nih.gov/pubmed/23979941
http://dx.doi.org/10.1534/g3.113.007948

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789811/
https://www.ncbi.nlm.nih.gov/pubmed/23979941
http://dx.doi.org/10.1534/g3.113.007948

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