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Reduced expression of bone morphogenetic protein receptor IA in pancreatic cancer is associated with a poor prognosis

BACKGROUND: The expression of SMAD4, the central component of the transforming growth factor-β (TGF-β) and bone morphogenetic protein (BMP) signalling pathways, is lost in 50% of pancreatic cancers and is associated with a poor survival. Although the TGF-β pathway has been extensively studied and ch...

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Detalles Bibliográficos
Autores principales:	Voorneveld, P W, Stache, V, Jacobs, R J, Smolders, E, Sitters, A I, Liesker, A, S Korkmaz, K, Lam, S M, De Miranda, N F C C, Morreau, H, Kodach, L L, Hardwick, J C H
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2013
Materias:	Molecular Diagnostics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790157/ https://www.ncbi.nlm.nih.gov/pubmed/23969729 http://dx.doi.org/10.1038/bjc.2013.486

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