Cargando…
PIAS4 is an activator of hypoxia signalling via VHL suppression during growth of pancreatic cancer cells
BACKGROUND: The PIAS4 protein belongs to the family of protein inhibitors of activated STAT, but has since been implicated in various biological activities including the post-translational modification known as sumoylation. In this study, we explored the roles of PIAS4 in pancreatic tumourigenesis....
Autores principales: | Chien, W, Lee, K L, Ding, L W, Wuensche, P, Kato, H, Doan, N B, Poellinger, L, Said, J W, Koeffler, H P |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790182/ https://www.ncbi.nlm.nih.gov/pubmed/24002598 http://dx.doi.org/10.1038/bjc.2013.531 |
Ejemplares similares
-
MicroRNA-18a modulates STAT3 activity through negative regulation of PIAS3 during gastric adenocarcinogenesis
por: Wu, W, et al.
Publicado: (2013) -
A hypoxia-dependent upregulation of hypoxia-inducible factor-1 by nuclear factor-κB promotes gastric tumour growth and angiogenesis
por: Nam, S Y, et al.
Publicado: (2011) -
The von Hippel–Lindau tumour suppressor gene: uncovering the expression of the pVHL172 isoform
por: Chesnel, F, et al.
Publicado: (2015) -
Absence of VHL gene alteration and high VEGF expression are associated with tumour aggressiveness and poor survival of renal-cell carcinoma
por: Patard, J-J, et al.
Publicado: (2009) -
Microvascular density and hypoxia-inducible factor pathway in pancreatic endocrine tumours: negative correlation of microvascular density and VEGF expression with tumour progression
por: Couvelard, A, et al.
Publicado: (2005)