Aerosolised 5-azacytidine suppresses tumour growth and reprogrammes the epigenome in an orthotopic lung cancer model

BACKGROUND: Epigenetic silencing by promoter methylation and chromatin remodelling affects hundreds of genes and is a causal event for lung cancer. Treatment of patients with low doses of the demethylating agent 5-azacytidine in combination with the histone deacetylase inhibitor entinostat has yield...

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Detalles Bibliográficos
Autores principales: Reed, M D, Tellez, C S, Grimes, M J, Picchi, M A, Tessema, M, Cheng, Y S, March, T H, Kuehl, P J, Belinsky, S A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790193/
https://www.ncbi.nlm.nih.gov/pubmed/24045660
http://dx.doi.org/10.1038/bjc.2013.575

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790193/
https://www.ncbi.nlm.nih.gov/pubmed/24045660
http://dx.doi.org/10.1038/bjc.2013.575

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