Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system

Technologies allowing for specific regulation of endogenous genes are valuable for the study of gene functions and have great potential in therapeutics. We created the CRISPR-on system, a two-component transcriptional activator consisting of a nuclease-dead Cas9 (dCas9) protein fused with a transcri...

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Detalles Bibliográficos
Autores principales: Cheng, Albert W, Wang, Haoyi, Yang, Hui, Shi, Linyu, Katz, Yarden, Theunissen, Thorold W, Rangarajan, Sudharshan, Shivalila, Chikdu S, Dadon, Daniel B, Jaenisch, Rudolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790238/
https://www.ncbi.nlm.nih.gov/pubmed/23979020
http://dx.doi.org/10.1038/cr.2013.122

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790238/
https://www.ncbi.nlm.nih.gov/pubmed/23979020
http://dx.doi.org/10.1038/cr.2013.122

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