The Discovery of a Reciprocal Relationship between Tyrosine-Kinase Signaling and Cullin Neddylation

While neddylation is known to activate cullin (CUL)-RING ubiquitin ligases (CRLs), its role in regulating T cell signaling is poorly understood. Using the investigational NEDD8 activating enzyme (NAE) inhibitor, MLN4924, we found that neddylation negatively regulates T cell receptor (TCR) signaling,...

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Detalles Bibliográficos
Autores principales: Friend, Samantha F., Peterson, Lisa K., Treacy, Eric, Stefanski, Adrianne L., Sosinowski, Tomasz, Pennock, Nathan D., Berger, Allison J., Winn, Virginia D., Dragone, Leonard L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790728/
https://www.ncbi.nlm.nih.gov/pubmed/24124476
http://dx.doi.org/10.1371/journal.pone.0075200

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790728/
https://www.ncbi.nlm.nih.gov/pubmed/24124476
http://dx.doi.org/10.1371/journal.pone.0075200

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