Ansamitocin P3 Depolymerizes Microtubules and Induces Apoptosis by Binding to Tubulin at the Vinblastine Site

Maytansinoid conjugates are currently under different phases of clinical trials and have been showing promising activity for various types of cancers. In this study, we have elucidated the mechanism of action of ansamitocin P3, a structural analogue of maytansine for its anticancer activity. Ansamit...

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Detalles Bibliográficos
Autores principales: Venghateri, Jubina B., Gupta, Tilak Kumar, Verma, Paul J., Kunwar, Ambarish, Panda, Dulal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790769/
https://www.ncbi.nlm.nih.gov/pubmed/24124473
http://dx.doi.org/10.1371/journal.pone.0075182

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790769/
https://www.ncbi.nlm.nih.gov/pubmed/24124473
http://dx.doi.org/10.1371/journal.pone.0075182

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