Inhibition of mTOR Reduces Anal Carcinogenesis in Transgenic Mouse Model

The molecular mechanism of human anal squamous cell carcinoma (ASCC) is unclear, and the accumulating evidence indicate association of ASCC with the activation of the Akt/mTOR pathway. Here we describe a mouse model with spontaneous anal squamous cell cancer, wherein a combined deletion of Tgfbr1 an...

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Detalles Bibliográficos
Autores principales: Sun, Zhi-Jun, Zhang, Lu, Zhang, Wei, Hall, Bradford, Bian, Yansong, Kulkarni, Ashok B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790781/
https://www.ncbi.nlm.nih.gov/pubmed/24124460
http://dx.doi.org/10.1371/journal.pone.0074888

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790781/
https://www.ncbi.nlm.nih.gov/pubmed/24124460
http://dx.doi.org/10.1371/journal.pone.0074888

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