Ouabain, a Cardiac Glycoside, Inhibits the Fanconi Anemia/BRCA Pathway Activated by DNA Interstrand Cross-Linking Agents

Modulation of the DNA repair pathway is an emerging target for the development of anticancer drugs. DNA interstrand cross-links (ICLs), one of the most severe forms of DNA damage caused by anticancer drugs such as cisplatin and mitomycin C (MMC), activates the Fanconi anemia (FA)/BRCA DNA repair pat...

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Detalles Bibliográficos
Autores principales: Wha Jun, Dong, Hwang, Mihwa, Kim, Hyun Jung, Hwang, Soo Kyung, Kim, Sunshin, Lee, Chang-Hun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790830/
https://www.ncbi.nlm.nih.gov/pubmed/24124520
http://dx.doi.org/10.1371/journal.pone.0075905

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790830/
https://www.ncbi.nlm.nih.gov/pubmed/24124520
http://dx.doi.org/10.1371/journal.pone.0075905

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