Mechanism of amyloid β−protein dimerization determined using single−molecule AFM force spectroscopy

Aβ42 and Aβ40 are the two primary alloforms of human amyloid β−protein (Aβ). The two additional C−terminal residues of Aβ42 result in elevated neurotoxicity compared with Aβ40, but the molecular mechanism underlying this effect remains unclear. Here, we used single−molecule force microscopy to chara...

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Detalles Bibliográficos
Autores principales: Lv, Zhengjian, Roychaudhuri, Robin, Condron, Margaret M., Teplow, David B., Lyubchenko, Yuri L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791449/
https://www.ncbi.nlm.nih.gov/pubmed/24096987
http://dx.doi.org/10.1038/srep02880

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791449/
https://www.ncbi.nlm.nih.gov/pubmed/24096987
http://dx.doi.org/10.1038/srep02880

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