Synthesis and Biological Evaluation of Novel Alkyl-Imidazolyl Carbinols and their Esters: Potent Antimycotics

A novel series of imidazol-5-yl carbinols and their 4-chlorobenzoyl esters has been synthesized by the Grignard reaction and subsequent esterification. These compounds were screened for their antimicrobial activities in an agar diffusion assay. The compounds with C(10) to C(12)-alkyl side chains dis...

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Detalles Bibliográficos
Autores principales: Krauss, Jürgen, Gratzl, Carina, Sturm, Verena, Müller, Christoph, Staudacher, Verena, Schmidt, Christoph Q., Bracher, Franz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Österreichische Apotheker-Verlagsgesellschaft 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791929/
https://www.ncbi.nlm.nih.gov/pubmed/24106663
http://dx.doi.org/10.3797/scipharm.1304-17
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author Krauss, Jürgen
Gratzl, Carina
Sturm, Verena
Müller, Christoph
Staudacher, Verena
Schmidt, Christoph Q.
Bracher, Franz
author_facet Krauss, Jürgen
Gratzl, Carina
Sturm, Verena
Müller, Christoph
Staudacher, Verena
Schmidt, Christoph Q.
Bracher, Franz
author_sort Krauss, Jürgen
collection PubMed
description A novel series of imidazol-5-yl carbinols and their 4-chlorobenzoyl esters has been synthesized by the Grignard reaction and subsequent esterification. These compounds were screened for their antimicrobial activities in an agar diffusion assay. The compounds with C(10) to C(12)-alkyl side chains displayed significant antimycotic activity.
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spelling pubmed-37919292013-10-08 Synthesis and Biological Evaluation of Novel Alkyl-Imidazolyl Carbinols and their Esters: Potent Antimycotics Krauss, Jürgen Gratzl, Carina Sturm, Verena Müller, Christoph Staudacher, Verena Schmidt, Christoph Q. Bracher, Franz Sci Pharm Research Article A novel series of imidazol-5-yl carbinols and their 4-chlorobenzoyl esters has been synthesized by the Grignard reaction and subsequent esterification. These compounds were screened for their antimicrobial activities in an agar diffusion assay. The compounds with C(10) to C(12)-alkyl side chains displayed significant antimycotic activity. Österreichische Apotheker-Verlagsgesellschaft 2013 2013-09-02 /pmc/articles/PMC3791929/ /pubmed/24106663 http://dx.doi.org/10.3797/scipharm.1304-17 Text en © Krauss et al.; licensee Österreichische Apotheker-Verlagsgesellschaft m. b. H., Vienna, Austria. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Krauss, Jürgen
Gratzl, Carina
Sturm, Verena
Müller, Christoph
Staudacher, Verena
Schmidt, Christoph Q.
Bracher, Franz
Synthesis and Biological Evaluation of Novel Alkyl-Imidazolyl Carbinols and their Esters: Potent Antimycotics
title Synthesis and Biological Evaluation of Novel Alkyl-Imidazolyl Carbinols and their Esters: Potent Antimycotics
title_full Synthesis and Biological Evaluation of Novel Alkyl-Imidazolyl Carbinols and their Esters: Potent Antimycotics
title_fullStr Synthesis and Biological Evaluation of Novel Alkyl-Imidazolyl Carbinols and their Esters: Potent Antimycotics
title_full_unstemmed Synthesis and Biological Evaluation of Novel Alkyl-Imidazolyl Carbinols and their Esters: Potent Antimycotics
title_short Synthesis and Biological Evaluation of Novel Alkyl-Imidazolyl Carbinols and their Esters: Potent Antimycotics
title_sort synthesis and biological evaluation of novel alkyl-imidazolyl carbinols and their esters: potent antimycotics
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791929/
https://www.ncbi.nlm.nih.gov/pubmed/24106663
http://dx.doi.org/10.3797/scipharm.1304-17
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