Rapid Inhibition of Pyruvate Dehydrogenase: An Initiating Event in High Dietary Fat-Induced Loss of Metabolic Flexibility in the Heart

Cardiac function depends on the ability to switch between fatty acid and glucose oxidation for energy production in response to changes in substrate availability and energetic stress. In obese and diabetic individuals, increased reliance on fatty acids and reduced metabolic flexibility are thought t...

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Detalles Bibliográficos
Autores principales: Crewe, Clair, Kinter, Michael, Szweda, Luke I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792029/
https://www.ncbi.nlm.nih.gov/pubmed/24116221
http://dx.doi.org/10.1371/journal.pone.0077280

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792029/
https://www.ncbi.nlm.nih.gov/pubmed/24116221
http://dx.doi.org/10.1371/journal.pone.0077280

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