Structural Differences between the Avian and Human H7N9 Hemagglutinin Proteins Are Attributable to Modifications in Salt Bridge Formation: A Computational Study with Implications in Viral Evolution

Influenza A hemagglutinin (HA) is a homotrimeric glycoprotein composed of a fibrous globular stem supporting a globular head containing three sialic acid binding sites responsible for infection. The H7N9 strain has consistently infected an avian host, however, the novel 2013 strain is now capable of...

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Detalles Bibliográficos
Autores principales: Cueno, Marni E., Imai, Kenichi, Tamura, Muneaki, Ochiai, Kuniyasu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792060/
https://www.ncbi.nlm.nih.gov/pubmed/24116152
http://dx.doi.org/10.1371/journal.pone.0076764

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792060/
https://www.ncbi.nlm.nih.gov/pubmed/24116152
http://dx.doi.org/10.1371/journal.pone.0076764

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