OptZyme: Computational Enzyme Redesign Using Transition State Analogues

OptZyme is a new computational procedure for designing improved enzymatic activity (i.e., k(cat) or k(cat)/K(M)) with a novel substrate. The key concept is to use transition state analogue compounds, which are known for many reactions, as proxies for the typically unknown transition state structures...

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Detalles Bibliográficos
Autores principales: Grisewood, Matthew J., Gifford, Nathanael P., Pantazes, Robert J., Li, Ye, Cirino, Patrick C., Janik, Michael J., Maranas, Costas D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792102/
https://www.ncbi.nlm.nih.gov/pubmed/24116038
http://dx.doi.org/10.1371/journal.pone.0075358

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792102/
https://www.ncbi.nlm.nih.gov/pubmed/24116038
http://dx.doi.org/10.1371/journal.pone.0075358

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