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OptZyme: Computational Enzyme Redesign Using Transition State Analogues
OptZyme is a new computational procedure for designing improved enzymatic activity (i.e., k(cat) or k(cat)/K(M)) with a novel substrate. The key concept is to use transition state analogue compounds, which are known for many reactions, as proxies for the typically unknown transition state structures...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792102/ https://www.ncbi.nlm.nih.gov/pubmed/24116038 http://dx.doi.org/10.1371/journal.pone.0075358 |