Applying Linear and Non-Linear Methods for Parallel Prediction of Volume of Distribution and Fraction of Unbound Drug

Volume of distribution and fraction unbound are two key parameters in pharmacokinetics. The fraction unbound describes the portion of free drug in plasma that may extravasate, while volume of distribution describes the tissue access and binding of a drug. Reliable in silico predictions of these phar...

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Detalles Bibliográficos
Autores principales: del Amo, Eva M., Ghemtio, Leo, Xhaard, Henri, Yliperttula, Marjo, Urtti, Arto, Kidron, Heidi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792104/
https://www.ncbi.nlm.nih.gov/pubmed/24116008
http://dx.doi.org/10.1371/journal.pone.0074758

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792104/
https://www.ncbi.nlm.nih.gov/pubmed/24116008
http://dx.doi.org/10.1371/journal.pone.0074758

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