Dissection of a Krox20 positive feedback loop driving cell fate choices in hindbrain patterning

Although feedback loops are essential in development, their molecular implementation and precise functions remain elusive. Using enhancer knockout in mice, we demonstrate that a direct, positive autoregulatory loop amplifies and maintains the expression of Krox20, a transcription factor governing ve...

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Detalles Bibliográficos
Autores principales: Bouchoucha, Yassine X, Reingruber, Jürgen, Labalette, Charlotte, Wassef, Michel A, Thierion, Elodie, Desmarquet-Trin Dinh, Carole, Holcman, David, Gilardi-Hebenstreit, Pascale, Charnay, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Molecular Biology Organization 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792346/
https://www.ncbi.nlm.nih.gov/pubmed/24061538
http://dx.doi.org/10.1038/msb.2013.46

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792346/
https://www.ncbi.nlm.nih.gov/pubmed/24061538
http://dx.doi.org/10.1038/msb.2013.46

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