A neuroprotective phase precedes striatal degeneration upon nucleolar stress

The nucleolus is implicated in sensing and responding to cellular stress by stabilizing p53. The pro-apoptotic effect of p53 is associated with several neurodegenerative disorders, including Huntington's disease (HD), which is characterized by the progressive loss of medium spiny neurons (MSNs)...

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Detalles Bibliográficos
Autores principales: Kreiner, G, Bierhoff, H, Armentano, M, Rodriguez-Parkitna, J, Sowodniok, K, Naranjo, J R, Bonfanti, L, Liss, B, Schütz, G, Grummt, I, Parlato, R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792439/
https://www.ncbi.nlm.nih.gov/pubmed/23764776
http://dx.doi.org/10.1038/cdd.2013.66

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792439/
https://www.ncbi.nlm.nih.gov/pubmed/23764776
http://dx.doi.org/10.1038/cdd.2013.66

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