A Ham1p-Dependent Mechanism and Modulation of the Pyrimidine Biosynthetic Pathway Can Both Confer Resistance to 5-Fluorouracil in Yeast

5-Fluorouracil (5-FU) is an anticancer drug and pyrimidine analogue. A problem in 5-FU therapy is acquired resistance to the drug. To find out more about the mechanisms of resistance, we screened a plasmid library in yeast for genes that confer 5-FU resistance when overexpressed. We cloned five gene...

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Detalles Bibliográficos
Autores principales: Carlsson, Mattias, Gustavsson, Marie, Hu, Guo-Zhen, Murén, Eva, Ronne, Hans
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792807/
https://www.ncbi.nlm.nih.gov/pubmed/24124444
http://dx.doi.org/10.1371/journal.pone.0052094

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792807/
https://www.ncbi.nlm.nih.gov/pubmed/24124444
http://dx.doi.org/10.1371/journal.pone.0052094

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