Mitochondrial Aminopeptidase Deletion Increases Chronological Lifespan and Oxidative Stress Resistance while Decreasing Respiratory Metabolism in S. cerevisiae

Recessive mutations in XPNPEP3, encoding a mitochondrial x-prolyl aminopeptidase, have been identified in families with a rare hereditary tubulointerstitial kidney disease. The yeast ortholog of XPNPEP3, Icp55p, participates in the proteolytic processing and stabilization of mitochondrial proteins a...

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Detalles Bibliográficos
Autores principales: Stames, Erine M., O'Toole, John F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792884/
https://www.ncbi.nlm.nih.gov/pubmed/24116217
http://dx.doi.org/10.1371/journal.pone.0077234

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792884/
https://www.ncbi.nlm.nih.gov/pubmed/24116217
http://dx.doi.org/10.1371/journal.pone.0077234

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