Epigenetic Priming of AML Blasts for All-trans Retinoic Acid-Induced Differentiation by the HDAC Class-I Selective Inhibitor Entinostat

All-trans retinoic acid (ATRA) has only limited single agent activity in AML without the PML-RARα fusion (non-M3 AML). In search of a sensitizing strategy to overcome this relative ATRA resistance, we investigated the potency of the HDAC class-I selective inhibitor entinostat in AML cell lines Kasum...

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Detalles Bibliográficos
Autores principales: Blagitko-Dorfs, Nadja, Jiang, Yi, Duque-Afonso, Jesús, Hiller, Jan, Yalcin, Arzu, Greve, Gabriele, Abdelkarim, Mahmoud, Hackanson, Björn, Lübbert, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792939/
https://www.ncbi.nlm.nih.gov/pubmed/24116031
http://dx.doi.org/10.1371/journal.pone.0075258

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792939/
https://www.ncbi.nlm.nih.gov/pubmed/24116031
http://dx.doi.org/10.1371/journal.pone.0075258

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