Sox2 Expression Is Regulated by a Negative Feedback Loop in Embryonic Stem Cells That Involves AKT Signaling and FoxO1

The self-renewal and pluripotency of embryonic stem cells (ESC) is regulated by a highly integrated network of essential transcription factors, which includes Sox2. Previous studies have shown that elevating Sox2 on its own in mouse ESC induces differentiation and inhibits the expression of endogeno...

Descripción completa

Detalles Bibliográficos
Autores principales: Ormsbee Golden, Briana D., Wuebben, Erin L., Rizzino, Angie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792943/
https://www.ncbi.nlm.nih.gov/pubmed/24116102
http://dx.doi.org/10.1371/journal.pone.0076345

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792943/
https://www.ncbi.nlm.nih.gov/pubmed/24116102
http://dx.doi.org/10.1371/journal.pone.0076345

Ejemplares similares