Recombinant Human Prion Protein Inhibits Prion Propagation in vitro

Prion diseases are associated with the conformational conversion of the cellular prion protein (PrP(C)) into the pathological scrapie isoform (PrP(Sc)) in the brain. Both the in vivo and in vitro conversion of PrP(C) into PrP(Sc) is significantly inhibited by differences in amino acid sequence betwe...

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Detalles Bibliográficos
Autores principales: Yuan, Jue, Zhan, Yi-An, Abskharon, Romany, Xiao, Xiangzhu, Martinez, Manuel Camacho, Zhou, Xiaochen, Kneale, Geoff, Mikol, Jacqueline, Lehmann, Sylvain, Surewicz, Witold K., Castilla, Joaquín, Steyaert, Jan, Zhang, Shulin, Kong, Qingzhong, Petersen, Robert B., Wohlkonig, Alexandre, Zou, Wen-Quan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793212/
https://www.ncbi.nlm.nih.gov/pubmed/24105336
http://dx.doi.org/10.1038/srep02911

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793212/
https://www.ncbi.nlm.nih.gov/pubmed/24105336
http://dx.doi.org/10.1038/srep02911

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