Insight into S-adenosylmethionine biosynthesis from the crystal structures of the human methionine adenosyltransferase catalytic and regulatory subunits

MAT (methionine adenosyltransferase) utilizes L-methionine and ATP to form SAM (S-adenosylmethionine), the principal methyl donor in biological methylation. Mammals encode a liver-specific isoenzyme, MAT1A, that is genetically linked with an inborn metabolic disorder of hypermethioninaemia, as well...

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Detalles Bibliográficos
Autores principales: Shafqat, Naeem, Muniz, Joao R. C., Pilka, Ewa S., Papagrigoriou, Evangelos, vonDelft, Frank, Oppermann, Udo, Yue, Wyatt W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793261/
https://www.ncbi.nlm.nih.gov/pubmed/23425511
http://dx.doi.org/10.1042/BJ20121580

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793261/
https://www.ncbi.nlm.nih.gov/pubmed/23425511
http://dx.doi.org/10.1042/BJ20121580

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