Anti-insulin-like growth factor-IIP3 DNAzymes inhibit cell proliferation and induce caspase-dependent apoptosis in human hepatocarcinoma cell lines

BACKGROUND: Insulin-like growth factor II (IGF-II) is a fetal growth protein and an important proangiogenic factor controlled by four promoters (P), of which P2–P4 are inactive in the adult liver. Reactivation and dysregulation of IGF-IIP3 in particular is associated with the attenuation of apoptosi...

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Detalles Bibliográficos
Autores principales: Zhang, Min, Drummen, Gregor PC, Luo, Su
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793593/
https://www.ncbi.nlm.nih.gov/pubmed/24115835
http://dx.doi.org/10.2147/DDDT.S48971

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793593/
https://www.ncbi.nlm.nih.gov/pubmed/24115835
http://dx.doi.org/10.2147/DDDT.S48971

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