Human platelets generate phospholipid-esterified prostaglandins via cyclooxygenase-1 that are inhibited by low dose aspirin supplementation

Oxidized phospholipids (oxPLs) generated nonenzymatically display pleiotropic biological actions in inflammation. Their generation by cellular cyclooxygenases (COXs) is currently unknown. To determine whether platelets generate prostaglandin (PG)-containing oxPLs, then characterize their structures...

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Detalles Bibliográficos
Autores principales: Aldrovandi, Maceler, Hammond, Victoria J., Podmore, Helen, Hornshaw, Martin, Clark, Stephen R., Marnett, Lawrence J., Slatter, David A., Murphy, Robert C., Collins, Peter W., O'Donnell, Valerie B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Biochemistry and Molecular Biology 2013
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793613/
https://www.ncbi.nlm.nih.gov/pubmed/23883581
http://dx.doi.org/10.1194/jlr.M041533

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793613/
https://www.ncbi.nlm.nih.gov/pubmed/23883581
http://dx.doi.org/10.1194/jlr.M041533

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