A T/C polymorphism in the GPX4 3′UTR affects the selenoprotein expression pattern and cell viability in transfected Caco-2 cells

BACKGROUND: Synthesis of selenoproteins such as glutathione peroxidases (GPx) requires a specific tRNA and a stem-loop structure in the 3′untranslated region (3′UTR) of the mRNA. A common single nucleotide polymorphism occurs in the GPX4 gene in a region corresponding to the 3′UTR. METHODS: The two...

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Detalles Bibliográficos
Autores principales: Gautrey, Hannah, Nicol, Fergus, Sneddon, Alan A., Hall, Judith, Hesketh, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Pub. Co 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793862/
https://www.ncbi.nlm.nih.gov/pubmed/21459128
http://dx.doi.org/10.1016/j.bbagen.2011.03.016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793862/
https://www.ncbi.nlm.nih.gov/pubmed/21459128
http://dx.doi.org/10.1016/j.bbagen.2011.03.016

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