Generation of Interleukin-2 Receptor Gamma Gene Knockout Pigs from Somatic Cells Genetically Modified by Zinc Finger Nuclease-Encoding mRNA

Zinc finger nuclease (ZFN) is a powerful tool for genome editing. ZFN-encoding plasmid DNA expression systems have been recently employed for the generation of gene knockout (KO) pigs, although one major limitation of this technology is the use of potentially harmful genome-integrating plasmid DNAs....

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Detalles Bibliográficos
Autores principales: Watanabe, Masahito, Nakano, Kazuaki, Matsunari, Hitomi, Matsuda, Taisuke, Maehara, Miki, Kanai, Takahiro, Kobayashi, Mirina, Matsumura, Yukina, Sakai, Rieko, Kuramoto, Momoko, Hayashida, Gota, Asano, Yoshinori, Takayanagi, Shuko, Arai, Yoshikazu, Umeyama, Kazuhiro, Nagaya, Masaki, Hanazono, Yutaka, Nagashima, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793986/
https://www.ncbi.nlm.nih.gov/pubmed/24130776
http://dx.doi.org/10.1371/journal.pone.0076478

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793986/
https://www.ncbi.nlm.nih.gov/pubmed/24130776
http://dx.doi.org/10.1371/journal.pone.0076478

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