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Generation of Interleukin-2 Receptor Gamma Gene Knockout Pigs from Somatic Cells Genetically Modified by Zinc Finger Nuclease-Encoding mRNA
Zinc finger nuclease (ZFN) is a powerful tool for genome editing. ZFN-encoding plasmid DNA expression systems have been recently employed for the generation of gene knockout (KO) pigs, although one major limitation of this technology is the use of potentially harmful genome-integrating plasmid DNAs....
Autores principales: | Watanabe, Masahito, Nakano, Kazuaki, Matsunari, Hitomi, Matsuda, Taisuke, Maehara, Miki, Kanai, Takahiro, Kobayashi, Mirina, Matsumura, Yukina, Sakai, Rieko, Kuramoto, Momoko, Hayashida, Gota, Asano, Yoshinori, Takayanagi, Shuko, Arai, Yoshikazu, Umeyama, Kazuhiro, Nagaya, Masaki, Hanazono, Yutaka, Nagashima, Hiroshi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793986/ https://www.ncbi.nlm.nih.gov/pubmed/24130776 http://dx.doi.org/10.1371/journal.pone.0076478 |
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