Cargando…

ESAT-6 and HspX Improve the Effectiveness of BCG to Induce Human Dendritic Cells-Dependent Th1 and NK Cells Activation

The limited efficacy of the BCG vaccine against tuberculosis is partly due to the missing expression of immunogenic proteins. We analyzed whether the addition to BCG of ESAT-6 and HspX, two Mycobacterium tuberculosis (Mtb) antigens, could enhance its capacity to activate human dendritic cells (DCs)....

Descripción completa

Detalles Bibliográficos
Autores principales:	Marongiu, Laura, Donini, Marta, Toffali, Lara, Zenaro, Elena, Dusi, Stefano
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794045/ https://www.ncbi.nlm.nih.gov/pubmed/24130733 http://dx.doi.org/10.1371/journal.pone.0075684

Ejemplares similares

Detection of anti-HspX antibodies and HspX protein in patient sera for the identification of recent latent infection by Mycobacterium tuberculosis
por: Castro-Garza, Jorge, et al.
Publicado: (2017)

HspX-mediated survival pathways of pathogenic mycobacteria
por: Alhusain, Fahad
Publicado: (2021)

HspX promotes the polar localization of mycobacterial protein aggregates
por: Zhang, Yi-Wei, et al.
Publicado: (2019)

Comparison of hspX gene sequence in the Beijing and non-Beijing Mycobacterium tuberculosis
por: Seyed Majidi, Ashkan, et al.
Publicado: (2020)

Evaluating the Performance of PPE44, HSPX, ESAT-6 and CFP-10 Factors in Tuberculosis Subunit Vaccines
por: Valizadeh, Azar, et al.
Publicado: (2022)

Humoral response to HspX and GlcB to previous and recent infection by Mycobacterium tuberculosis
por: Rabahi, Marcelo Fouad, et al.
Publicado: (2007)

Diagnostic potential of 16 kDa (HspX, α-crystalline) antigen for serodiagnosis of tuberculosis
por: Kaushik, Amit, et al.
Publicado: (2012)

HspX-mediated protection against tuberculosis depends on its chaperoning of a mycobacterial molecule
por: Taylor, Jennifer L, et al.
Publicado: (2012)

Development and Evaluation of a Fusion Polyprotein Based on HspX and Other Antigen Sequences for the Serodiagnosis of Tuberculosis
por: Zhou, Fangbin, et al.
Publicado: (2021)

The use of Mycobacterium tuberculosis HspX and GlcB proteins to identify latent tuberculosis in rheumatoid arthritis patients
por: Silva, Bruna Daniella Souza, et al.
Publicado: (2013)

IL-10 down-regulates the expression of survival associated gene hspX of Mycobacterium tuberculosis in murine macrophage
por: Jee, Babban, et al.
Publicado: (2017)

Rv2031c of Mycobacterium tuberculosis: a master regulator of Rv2028–Rv2031 (HspX) operon
por: Mushtaq, Khurram, et al.
Publicado: (2015)

Enhancement of the Local CD8(+) T-Cellular Immune Response to Mycobacterium tuberculosis in BCG-Primed Mice after Intranasal Administration of Influenza Vector Vaccine Carrying TB10.4 and HspX Antigens
por: Vasilyev, Kirill, et al.
Publicado: (2021)

Detection of Mycobacterium tuberculosis GlcB or HspX Antigens or devR DNA Impacts the Rapid Diagnosis of Tuberculous Meningitis in Children
por: Haldar, Sagarika, et al.
Publicado: (2012)

Modulation of Macrophage Responses by CMX, a Fusion Protein Composed of Ag85c, MPT51, and HspX from Mycobacterium tuberculosis
por: da Costa, Adeliane C., et al.
Publicado: (2017)

Evaluation of the immunotoxicity and allergenicity of a new intranasal influenza vector vaccine against tuberculosis carrying TB10.4 and HspX antigens
por: Stosman, Kira I., et al.
Publicado: (2023)

A new DNA vaccine expressing HspX-PPE44-EsxV fusion antigens of Mycobacterium tuberculosis induced strong immune responses
por: Moradi, Bagher, et al.
Publicado: (2020)

Mucosal Influenza Vector Vaccine Carrying TB10.4 and HspX Antigens Provides Protection against Mycobacterium tuberculosis in Mice and Guinea Pigs
por: Sergeeva, Mariia, et al.
Publicado: (2021)

Formulation and Optimization of a New Cationic Lipid-Modified PLGA Nanoparticle as Delivery System for Mycobacterium tuberculosis HspX/EsxS Fusion Protein: An Experimental Design
por: Khademi, Farzad, et al.
Publicado: (2019)

Immunogenicity of a Fusion Protein Containing Immunodominant Epitopes of Ag85C, MPT51, and HspX from Mycobacterium tuberculosis in Mice and Active TB Infection
por: de Sousa, Eduardo Martins, et al.
Publicado: (2012)

Correction: Immunogenicity of a Fusion Protein Containing Immunodominant Epitopes of Ag85C, MPT51, and HspX from Mycobacterium tuberculosis in Mice and Active TB Infection
por: de Sousa, Eduardo Martins, et al.
Publicado: (2013)

Oxyresveratrol Inhibits R848-Induced Pro-Inflammatory Mediators Release by Human Dendritic Cells Even When Embedded in PLGA Nanoparticles
por: Gaglio, Salvatore Calogero, et al.
Publicado: (2021)

Diversity of Epigenetic Features of the Inactive X-Chromosome in NK Cells, Dendritic Cells, and Macrophages
por: Syrett, Camille M., et al.
Publicado: (2019)

Effects of Cytokine Milieu Secreted by BCG-treated Dendritic Cells on Allergen-Specific Th Immune Response
por: Koh, Youngil I., et al.
Publicado: (2004)

Effects of Magnetic Nanoparticles on the Functional Activity of Human Monocytes and Dendritic Cells
por: Donini, Marta, et al.
Publicado: (2023)

Introducing the ESAT-6 free IGRA, a companion diagnostic for TB vaccines based on ESAT-6
por: Ruhwald, Morten, et al.
Publicado: (2017)

Biogenic selenium nanoparticles: characterization, antimicrobial activity and effects on human dendritic cells and fibroblasts
por: Cremonini, Eleonora, et al.
Publicado: (2016)

Alpha4 beta7 integrin controls Th17 cell trafficking in the spinal cord leptomeninges during experimental autoimmune encephalomyelitis
por: Rossi, Barbara, et al.
Publicado: (2023)

CAR T Cells Targeting Membrane-Bound Hsp70 on Tumor Cells Mimic Hsp70-Primed NK Cells
por: Bashiri Dezfouli, Ali, et al.
Publicado: (2022)

Plasmacytoid Dendritic Cell, Slan(+)-Monocyte and Natural Killer Cell Counts Function as Blood Cell-Based Biomarkers for Predicting Responses to Immune Checkpoint Inhibitor Monotherapy in Non-Small Cell Lung Cancer Patients
por: Pettinella, Francesca, et al.
Publicado: (2023)

ESAT-6 Targeting to DEC205+ Antigen Presenting Cells Induces Specific-T Cell Responses against ESAT-6 and Reduces Pulmonary Infection with Virulent Mycobacterium tuberculosis
por: Silva-Sánchez, Aarón, et al.
Publicado: (2015)

LFA-1 Controls Th1 and Th17 Motility Behavior in the Inflamed Central Nervous System
por: Dusi, Silvia, et al.
Publicado: (2019)

Mycobacterium tuberculosis ESAT6 Drives the Activation and Maturation of Bone Marrow-Derived Dendritic Cells via TLR4-Mediated Signaling
por: Jang, Ah-Ra, et al.
Publicado: (2019)

Human NK Cells Lyse Th2-Polarizing Dendritic Cells via NKp30 and DNAM-1
por: Walwyn-Brown, Katherine, et al.
Publicado: (2018)

BCG Moreau Vaccine Safety Profile and NK Cells—Double Protection Against Disseminated BCG Infection in Retrospective Study of BCG Vaccination in 52 Polish Children with Severe Combined Immunodeficiency
por: Bernatowska, Ewa, et al.
Publicado: (2019)

NKG2D is a Key Receptor for Recognition of Bladder Cancer Cells by IL-2-Activated NK Cells and BCG Promotes NK Cell Activation
por: García-Cuesta, Eva María, et al.
Publicado: (2015)

Adult-Like Anti-Mycobacterial T Cell and In Vivo Dendritic Cell Responses Following Neonatal Immunization with Ag85B-ESAT-6 in the IC31® Adjuvant
por: Kamath, Arun T., et al.
Publicado: (2008)

The Glycosylated Rv1860 Protein of Mycobacterium tuberculosis Inhibits Dendritic Cell Mediated TH1 and TH17 Polarization of T Cells and Abrogates Protective Immunity Conferred by BCG
por: Satchidanandam, Vijaya, et al.
Publicado: (2014)

Dendritic Cell Activity Driven by Recombinant Mycobacterium bovis BCG Producing Human IL-18, in Healthy BCG Vaccinated Adults
por: Szpakowski, Piotr, et al.
Publicado: (2015)

ESAT-6 undergoes self-association at phagosomal pH and an ESAT-6 specific nanobody restricts M. tuberculosis growth in macrophages
por: Bates, Timothy A, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_6qafpf9khttbeo48ifuvofi3ue