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MARCH5 inactivation supports mitochondrial function during neurodegenerative stress

Neuronal cell death is accompanied by mitochondrial dysfunction with mitochondrial maintenance critical to neuronal survival. The mitochondrial ubiquitin ligase MARCH5 has dual roles in the upkeep of mitochondrial function. MARCH5 is involved in targeted degradation of proteins harmful to mitochondr...

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Detalles Bibliográficos
Autores principales: Fang, Lei, Li, Jia, Flammer, Josef, Neutzner, Albert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794199/
https://www.ncbi.nlm.nih.gov/pubmed/24133412
http://dx.doi.org/10.3389/fncel.2013.00176