Conformational changes of the phenyl and naphthyl isocyanate-DNA adducts during DNA replication and by minor groove binding molecules

DNA lesions produced by aromatic isocyanates have an extra bulky group on the nucleotide bases, with the capability of forming stacking interaction within a DNA helix. In this work, we investigated the conformation of the 2′-deoxyadenosine and 2′-deoxycytidine derivatives tethering a phenyl or napht...

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Detalles Bibliográficos
Autores principales: Nakano, Shu-ichi, Uotani, Yuuki, Sato, Yuichi, Oka, Hirohito, Fujii, Masayuki, Sugimoto, Naoki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794578/
https://www.ncbi.nlm.nih.gov/pubmed/23873956
http://dx.doi.org/10.1093/nar/gkt608

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794578/
https://www.ncbi.nlm.nih.gov/pubmed/23873956
http://dx.doi.org/10.1093/nar/gkt608

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