HCV IRES interacts with the 18S rRNA to activate the 40S ribosome for subsequent steps of translation initiation

Previous analyses of complexes of 40S ribosomal subunits with the hepatitis C virus (HCV) internal ribosome entry site (IRES) have revealed contacts made by the IRES with ribosomal proteins. Here, using chemical probing, we show that the HCV IRES also contacts the backbone and bases of the CCC tripl...

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Detalles Bibliográficos
Autores principales: Malygin, Alexey A., Kossinova, Olga A., Shatsky, Ivan N., Karpova, Galina G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794592/
https://www.ncbi.nlm.nih.gov/pubmed/23873958
http://dx.doi.org/10.1093/nar/gkt632

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794592/
https://www.ncbi.nlm.nih.gov/pubmed/23873958
http://dx.doi.org/10.1093/nar/gkt632

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