Assessing the Effect of Loop Mutations in the Folding Space of β(2)-Microglobulin with Molecular Dynamics Simulations

We use molecular dynamics simulations of a full atomistic Gō model to explore the impact of selected DE-loop mutations (D59P and W60C) on the folding space of protein human β(2)-microglobulin (Hβ(2)m), the causing agent of dialysis-related amyloidosis, a conformational disorder characterized by the...

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Detalles Bibliográficos
Autores principales: Estácio, Sílvia G., Shakhnovich, Eugene I., Faísca, Patrícia F. N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794727/
https://www.ncbi.nlm.nih.gov/pubmed/23975166
http://dx.doi.org/10.3390/ijms140917256

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794727/
https://www.ncbi.nlm.nih.gov/pubmed/23975166
http://dx.doi.org/10.3390/ijms140917256

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