A Role for Cytosolic Isocitrate Dehydrogenase as a Negative Regulator of Glucose Signaling for Insulin Secretion in Pancreatic ß-Cells

Cytosolic NADPH may act as one of the signals that couple glucose metabolism to insulin secretion in the pancreatic ß-cell. NADPH levels in the cytoplasm are largely controlled by the cytosolic isoforms of malic enzyme and isocitrate dehydrogenase (IDHc). Some studies have provided evidence for a ro...

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Detalles Bibliográficos
Autores principales: Guay, Claudiane, Joly, Érik, Pepin, Émilie, Barbeau, Annie, Hentsch, Lisa, Pineda, Marco, Madiraju, S. R. Murthy, Brunengraber, Henri, Prentki, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795013/
https://www.ncbi.nlm.nih.gov/pubmed/24130841
http://dx.doi.org/10.1371/journal.pone.0077097

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795013/
https://www.ncbi.nlm.nih.gov/pubmed/24130841
http://dx.doi.org/10.1371/journal.pone.0077097

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