SLP-76 Sterile α Motif (SAM) and Individual H5 α Helix Mediate Oligomer Formation for Microclusters and T-cell Activation

Despite the importance of the immune adaptor SLP-76 in T-cell immunity, it has been unclear whether SLP-76 directly self-associates to form higher order oligomers for T-cell activation. In this study, we show that SLP-76 self-associates in response to T-cell receptor ligation as mediated by the N-te...

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Detalles Bibliográficos
Autores principales: Liu, Hebin, Thaker, Youg Raj, Stagg, Loren, Schneider, Helga, Ladbury, John E., Rudd, Christopher E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Signal Transduction
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795252/
https://www.ncbi.nlm.nih.gov/pubmed/23935094
http://dx.doi.org/10.1074/jbc.M112.424846

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795252/
https://www.ncbi.nlm.nih.gov/pubmed/23935094
http://dx.doi.org/10.1074/jbc.M112.424846

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