A Pivotal Role for Tryptophan 447 in Enzymatic Coupling of Human Endothelial Nitric Oxide Synthase (eNOS): EFFECTS ON TETRAHYDROBIOPTERIN-DEPENDENT CATALYSIS AND eNOS DIMERIZATION

Tetrahydrobiopterin (BH4) is a required cofactor for the synthesis of NO by NOS. Bioavailability of BH4 is a critical factor in regulating the balance between NO and superoxide production by endothelial NOS (eNOS coupling). Crystal structures of the mouse inducible NOS oxygenase domain reveal a homo...

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Detalles Bibliográficos
Autores principales: Benson, Matthew A., Batchelor, Helen, Chuaiphichai, Surawee, Bailey, Jade, Zhu, Hanneng, Stuehr, Dennis J., Bhattacharya, Shoumo, Channon, Keith M., Crabtree, Mark J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Enzymology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795282/
https://www.ncbi.nlm.nih.gov/pubmed/23965989
http://dx.doi.org/10.1074/jbc.M113.493023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795282/
https://www.ncbi.nlm.nih.gov/pubmed/23965989
http://dx.doi.org/10.1074/jbc.M113.493023

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