Hydrogen-bond network and pH sensitivity in human transthyretin

Transthyretin (TTR) is a tetrameric protein. TTR misfolding and aggregation are associated with human amyloid diseases. Dissociation of the TTR tetramer is believed to be the rate-limiting step in the amyloid fibril formation cascade. Low pH is known to promote dissociation into monomer and the form...

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Detalles Bibliográficos
Autores principales: Yokoyama, Takeshi, Mizuguchi, Mineyuki, Nabeshima, Yuko, Kusaka, Katsuhiro, Yamada, Taro, Hosoya, Takaaki, Ohhara, Takashi, Kurihara, Kazuo, Tanaka, Ichiro, Niimura, Nobuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2013
Materias:
Diffraction Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795539/
https://www.ncbi.nlm.nih.gov/pubmed/24121323
http://dx.doi.org/10.1107/S090904951302075X

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795539/
https://www.ncbi.nlm.nih.gov/pubmed/24121323
http://dx.doi.org/10.1107/S090904951302075X

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