Cargando…
Hydrogen-bond network and pH sensitivity in human transthyretin
Transthyretin (TTR) is a tetrameric protein. TTR misfolding and aggregation are associated with human amyloid diseases. Dissociation of the TTR tetramer is believed to be the rate-limiting step in the amyloid fibril formation cascade. Low pH is known to promote dissociation into monomer and the form...
Autores principales: | Yokoyama, Takeshi, Mizuguchi, Mineyuki, Nabeshima, Yuko, Kusaka, Katsuhiro, Yamada, Taro, Hosoya, Takaaki, Ohhara, Takashi, Kurihara, Kazuo, Tanaka, Ichiro, Niimura, Nobuo |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795539/ https://www.ncbi.nlm.nih.gov/pubmed/24121323 http://dx.doi.org/10.1107/S090904951302075X |
Ejemplares similares
-
Evaluation of performance for IBARAKI biological crystal diffractometer iBIX with new detectors
por: Kusaka, Katsuhiro, et al.
Publicado: (2013) -
Fundamental studies for the proton polarization technique in neutron protein crystallography
por: Tanaka, Ichiro, et al.
Publicado: (2013) -
Hydrogen bonds of DsrD protein revealed by neutron crystallography
por: Chatake, Toshiyuki, et al.
Publicado: (2008) -
Crystallization and evaluation of hen egg-white lysozyme crystals for protein pH titration in the crystalline state
por: Iwai, Wakari, et al.
Publicado: (2008) -
Phase-diagram-guided method for growth of a large crystal of glycoside hydrolase family 45 inverting cellulase suitable for neutron structural analysis
por: Nakamura, Akihiko, et al.
Publicado: (2013)