Molecular Characterization of Monoclonal Antibodies that Inhibit Acetylcholinesterase by Targeting the Peripheral Site and Backdoor Region

The inhibition properties and target sites of monoclonal antibodies (mAbs) Elec403, Elec408 and Elec410, generated against Electrophorus electricus acetylcholinesterase (AChE), have been defined previously using biochemical and mutagenesis approaches. Elec403 and Elec410, which bind competitively wi...

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Detalles Bibliográficos
Autores principales: Bourne, Yves, Renault, Ludovic, Essono, Sosthène, Mondielli, Grégoire, Lamourette, Patricia, Boquet, Didier, Grassi, Jacques, Marchot, Pascale
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795623/
https://www.ncbi.nlm.nih.gov/pubmed/24146971
http://dx.doi.org/10.1371/journal.pone.0077226

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795623/
https://www.ncbi.nlm.nih.gov/pubmed/24146971
http://dx.doi.org/10.1371/journal.pone.0077226

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