Cargando…
Toxicity and Immunogenicity of Enterotoxigenic Escherichia coli Heat-Labile and Heat-Stable Toxoid Fusion 3xSTa(A14Q)-LT(S63K/R192G/L211A) in a Murine Model
Diarrhea is the second leading cause of death to young children. Enterotoxigenic Escherichia coli (ETEC) are the most common bacteria causing diarrhea. Adhesins and enterotoxins are the virulence determinants in ETEC diarrhea. Adhesins mediate bacterial attachment and colonization, and enterotoxins...
Autores principales: | Zhang, Chengxian, Knudsen, David E., Liu, Mei, Robertson, Donald C., Zhang, Weiping |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795625/ https://www.ncbi.nlm.nih.gov/pubmed/24146989 http://dx.doi.org/10.1371/journal.pone.0077386 |
Ejemplares similares
-
Modified Heat-Stable Toxins (hSTa) of Enterotoxigenic Escherichia coli Lose Toxicity but Display Antigenicity after Being Genetically Fused to Heat-Labile Toxoid LT(R192G)
por: Liu, Mei, et al.
Publicado: (2011) -
Co-administered Tag-Less Toxoid Fusion 3xSTa(N12S)-mnLT(R192G/L211A) and CFA/I/II/IV MEFA (Multiepitope Fusion Antigen) Induce Neutralizing Antibodies to 7 Adhesins (CFA/I, CS1-CS6) and Both Enterotoxins (LT, STa) of Enterotoxigenic Escherichia coli (ETEC)
por: Duan, Qiangde, et al.
Publicado: (2018) -
Expression of proteins Heat-Labile (Lt-1) and Heat-Stable (STa) Escherichia coli expression of proteins Heat-Labile (Lt-1) and Heat-Stable (STa) Escherichia coli
por: Cavalcante, Alessandra, et al.
Publicado: (2014) -
Genetic Fusions of a CFA/I/II/IV MEFA (Multiepitope Fusion Antigen) and a Toxoid Fusion of Heat-Stable Toxin (STa) and Heat-Labile Toxin (LT) of Enterotoxigenic Escherichia coli (ETEC) Retain Broad Anti-CFA and Antitoxin Antigenicity
por: Ruan, Xiaosai, et al.
Publicado: (2015) -
Antibodies derived from a toxoid MEFA (multiepitope fusion antigen) show neutralizing activities against heat-labile toxin (LT), heat-stable toxins (STa, STb), and Shiga toxin 2e (Stx2e) of porcine enterotoxigenic Escherichia coli (ETEC)
por: Rausch, Dana, et al.
Publicado: (2017)