Combinatorial Optimization of Cystine-Knot Peptides towards High-Affinity Inhibitors of Human Matriptase-1

Cystine-knot miniproteins define a class of bioactive molecules with several thousand natural members. Their eponymous motif comprises a rigid structured core formed by six disulfide-connected cysteine residues, which accounts for its exceptional stability towards thermic or proteolytic degradation....

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Detalles Bibliográficos
Autores principales: Glotzbach, Bernhard, Reinwarth, Michael, Weber, Niklas, Fabritz, Sebastian, Tomaszowski, Michael, Fittler, Heiko, Christmann, Andreas, Avrutina, Olga, Kolmar, Harald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795654/
https://www.ncbi.nlm.nih.gov/pubmed/24146945
http://dx.doi.org/10.1371/journal.pone.0076956

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795654/
https://www.ncbi.nlm.nih.gov/pubmed/24146945
http://dx.doi.org/10.1371/journal.pone.0076956

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