Endogenous Human MDM2-C Is Highly Expressed in Human Cancers and Functions as a p53-Independent Growth Activator

Human cancers over-expressing mdm2, through a T to G variation at a single nucleotide polymorphism at position 309 (mdm2 SNP309), have functionally inactivated p53 that is not effectively degraded. They also have high expression of the alternatively spliced transcript, mdm2-C. Alternatively spliced...

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Detalles Bibliográficos
Autores principales: Okoro, Danielle R., Arva, Nicoleta, Gao, Chong, Polotskaia, Alla, Puente, Cindy, Rosso, Melissa, Bargonetti, Jill
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795673/
https://www.ncbi.nlm.nih.gov/pubmed/24147044
http://dx.doi.org/10.1371/journal.pone.0077643

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795673/
https://www.ncbi.nlm.nih.gov/pubmed/24147044
http://dx.doi.org/10.1371/journal.pone.0077643

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