Persistent Inhibition of ABL Tyrosine Kinase Causes Enhanced Apoptotic Response to TRAIL and Disrupts the Pro-Apoptotic Effect of Chloroquine

TNF-Related Apoptosis Inducing Ligand (TRAIL) binds to and activates death receptors to stimulate caspase-8 and apoptosis with higher efficiency in cancer than normal cells but the development of apoptosis resistance has limited its clinical efficacy. We found that stable, but not transient knockdow...

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Detalles Bibliográficos
Autores principales: Sridevi, Priya, Nhiayi, May K., Setten, Ryan L., Wang, Jean Y. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795698/
https://www.ncbi.nlm.nih.gov/pubmed/24147007
http://dx.doi.org/10.1371/journal.pone.0077495

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795698/
https://www.ncbi.nlm.nih.gov/pubmed/24147007
http://dx.doi.org/10.1371/journal.pone.0077495

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