Induction of Autophagy Is an Early Response to Gefitinib and a Potential Therapeutic Target in Breast Cancer

Gefitinib (Iressa(®), ZD1839) is a small molecule inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase. We report on an early cellular response to gefitinib that involves induction of functional autophagic flux in phenotypically diverse breast cancer cells that were sensitive (BT...

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Detalles Bibliográficos
Autores principales: Dragowska, Wieslawa H., Weppler, Sherry A., Wang, Jun Chih, Wong, Ling Yan, Kapanen, Anita I., Rawji, Jenna S., Warburton, Corinna, Qadir, Mohammed A., Donohue, Elizabeth, Roberge, Michel, Gorski, Sharon M., Gelmon, Karen A., Bally, Marcel B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795739/
https://www.ncbi.nlm.nih.gov/pubmed/24146879
http://dx.doi.org/10.1371/journal.pone.0076503

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795739/
https://www.ncbi.nlm.nih.gov/pubmed/24146879
http://dx.doi.org/10.1371/journal.pone.0076503

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