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Mathematical Modeling of the Role of Mitochondrial Fusion and Fission in Mitochondrial DNA Maintenance

Accumulation of mitochondrial DNA (mtDNA) mutations has been implicated in a wide range of human pathologies, including neurodegenerative diseases, sarcopenia, and the aging process itself. In cells, mtDNA molecules are constantly turned over (i.e. replicated and degraded) and are also exchanged amo...

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Detalles Bibliográficos
Autores principales: Tam, Zhi Yang, Gruber, Jan, Halliwell, Barry, Gunawan, Rudiyanto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795767/
https://www.ncbi.nlm.nih.gov/pubmed/24146842
http://dx.doi.org/10.1371/journal.pone.0076230