The Role of Protein Denaturation Energetics and Molecular Chaperones in the Aggregation and Mistargeting of Mutants Causing Primary Hyperoxaluria Type I

Primary hyperoxaluria type I (PH1) is a conformational disease which result in the loss of alanine:glyoxylate aminotransferase (AGT) function. The study of AGT has important implications for protein folding and trafficking because PH1 mutants may cause protein aggregation and mitochondrial mistarget...

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Detalles Bibliográficos
Autores principales: Mesa-Torres, Noel, Fabelo-Rosa, Israel, Riverol, Debora, Yunta, Cristina, Albert, Armando, Salido, Eduardo, Pey, Angel L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796444/
https://www.ncbi.nlm.nih.gov/pubmed/24205397
http://dx.doi.org/10.1371/journal.pone.0071963

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796444/
https://www.ncbi.nlm.nih.gov/pubmed/24205397
http://dx.doi.org/10.1371/journal.pone.0071963

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