Maintenance of pluripotency in mouse ES cells without Trp53

Tumor suppressor Trp53 works as a guardian of the genome in somatic cells. In mouse embryonic stem (ES) cells, it was reported that Trp53 represses pluripotency-associated transcription factor Nanog to induce differentiation. However, since Trp53-null mice develop to term, Trp53 is dispensable for b...

Descripción completa

Detalles Bibliográficos
Autores principales: Shigeta, Masaki, Ohtsuka, Satoshi, Nishikawa-Torikai, Satomi, Yamane, Mariko, Fujii, Setsuko, Murakami, Kazuhiro, Niwa, Hitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796736/
https://www.ncbi.nlm.nih.gov/pubmed/24126347
http://dx.doi.org/10.1038/srep02944

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796736/
https://www.ncbi.nlm.nih.gov/pubmed/24126347
http://dx.doi.org/10.1038/srep02944

Ejemplares similares